1/4/2024 0 Comments Monit drug![]() Off-label use means that a clinician prescribes the medication for an indication that was not researched and approved by the FDA. However, there are many off-label uses for this drug. ![]() Topiramate, like many other pharmaceuticals, is only FDA-approved for a few conditions. ![]() There are many off-label uses for topiramate, including neuropathic pain, psychotropic drug-induced weight gain, alcohol use disorders with tobacco dependence, cluster headache prevention, binge eating disorder, bulimia nervosa, obesity with hypertension, prevention of neuralgiform attacks, adjunctive therapy in bipolar disorder, unipolar depression, borderline personality disorder, obsessive-compulsive disorder, posttraumatic stress disorder, Tourette syndrome, Prader-Willie syndrome, essential tremor. For individuals with a body mass index over 30, topiramate has approval for chronic weight management. For migraine disorder, topiramate has approval for prophylaxis in adults (FDA, 2012). Adjunctive therapy is approved for adults and pediatric populations ages 2 to 16 with primary generalized onset tonic-clonic seizures, partial-onset seizures, and those two years or older with Lennox-Gastaut syndrome-associated seizures. It has received approval for monotherapy in epilepsy in those two years or older with primary generalized onset tonic-clonic seizures or partial-onset seizures. Specifically, topiramate is an anticonvulsant drug that was initially FDA approved in 1996 for the treatment of monotherapy epilepsy, adjunctive therapy epilepsy, and migraine disorder. The primary indication for this family of drugs is treating seizure disorders, hence the name "antiepileptic drugs." These are classically used as mood stabilizers in psychiatry, although their administrations have seen a broader application. AEDs are generally used for neurologic and psychiatric purposes. Topiramate is a compound that belongs to the family of medications called antiepileptic drugs (AEDs).
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